There are
636 mi
from Youngstown, OH to Cape Girardeau, MO
That's the driving distance. It would take 12 hours 12 mins to go from Youngstown, Ohio to Cape Girardeau, Missouri.
The flight distance (direct flight from Youngstown, OH to Cape Girardeau, MO) is 542 mi.
636 mi = 1,024.12 kms