There are
1,577 mi
from Yankton, SD to Simi Valley, CA
That's the driving distance. It would take 1 day 4 hours to go from Yankton, South Dakota to Simi Valley, California.
The flight distance (direct flight from Yankton, SD to Simi Valley, CA) is 1,293.92 mi.
1,577 mi = 2,538.01 kms