There are
1,603 mi
from Yankton, SD to Poway, CA
That's the driving distance. It would take 1 day 4 hours to go from Yankton, South Dakota to Poway, California.
The flight distance (direct flight from Yankton, SD to Poway, CA) is 1,265.79 mi.
1,603 mi = 2,580.08 kms