There are
2,880 mi
from Wilmington, NC to San Mateo, CA
That's the driving distance. It would take 2 days 3 hours to go from Wilmington, North Carolina to San Mateo, California.
The flight distance (direct flight from Wilmington, NC to San Mateo, CA) is 2,471.84 mi.
2,880 mi = 3.22 kms