There are
412 mi
from Waukegan, IL to Cape Girardeau, MO
That's the driving distance. It would take 7 hours 50 mins to go from Waukegan, Illinois to Cape Girardeau, Missouri.
The flight distance (direct flight from Waukegan, IL to Cape Girardeau, MO) is 360.53 mi.
412 mi = 662.60 kms