There are
1,446 mi
from Waterloo, IA to Mesquite, NV
That's the driving distance. It would take 1 day 1 hour to go from Waterloo, Iowa to Mesquite, Nevada.
The flight distance (direct flight from Waterloo, IA to Mesquite, NV) is 1,216.62 mi.
1,446 mi = 2,326.54 kms