There are
322 mi
from Waterloo, IA to Manitowoc, WI
That's the driving distance. It would take 6 hours 24 mins to go from Waterloo, Iowa to Manitowoc, Wisconsin.
The flight distance (direct flight from Waterloo, IA to Manitowoc, WI) is 260.10 mi.
322 mi = 518.75 kms