There are
1,623 mi
from Waltham, MA to Opelousas, LA
That's the driving distance. It would take 1 day 6 hours to go from Waltham, Massachusetts to Opelousas, Louisiana.
The flight distance (direct flight from Waltham, MA to Opelousas, LA) is 1,412 mi.
1,623 mi = 2,611.54 kms