There are
959 mi
from Waltham, MA to Jeffersonville, IN
That's the driving distance. It would take 18 hours 16 mins to go from Waltham, Massachusetts to Jeffersonville, Indiana.
The flight distance (direct flight from Waltham, MA to Jeffersonville, IN) is 813.38 mi.
959 mi = 1,544.15 kms