There are
1,373 mi
from Waltham, MA to Clarksdale, MS
That's the driving distance. It would take 1 day 2 hours to go from Waltham, Massachusetts to Clarksdale, Mississippi.
The flight distance (direct flight from Waltham, MA to Clarksdale, MS) is 1,187.13 mi.
1,373 mi = 2,209.06 kms