There are
1,812 mi
from Upland, CA to Sikeston, MO
That's the driving distance. It would take 1 day 8 hours to go from Upland, California to Sikeston, Missouri.
The flight distance (direct flight from Upland, CA to Sikeston, MO) is 1,584.52 mi.
1,812 mi = 1.61 kms