There are
726 mi
from Upland, CA to Las Cruces, NM
That's the driving distance. It would take 12 hours 43 mins to go from Upland, California to Las Cruces, New Mexico.
The flight distance (direct flight from Upland, CA to Las Cruces, NM) is 640.73 mi.
726 mi = 1,168.75 kms