There are
2,350 mi
from Upland, CA to Cayce, SC
That's the driving distance. It would take 1 day 17 hours to go from Upland, California to Cayce, South Carolina.
The flight distance (direct flight from Upland, CA to Cayce, SC) is 2,082.80 mi.
2,350 mi = 3.22 kms