There are
1,841 mi
from Upland, CA to Cape Girardeau, MO
That's the driving distance. It would take 1 day 8 hours to go from Upland, California to Cape Girardeau, Missouri.
The flight distance (direct flight from Upland, CA to Cape Girardeau, MO) is 1,587.86 mi.
1,841 mi = 2,962.39 kms