Miles between Tuscaloosa, AL and Simpsonville, SC

There are
356 mi
from Tuscaloosa, AL to Simpsonville, SC

That's the driving distance. It would take 6 hours 39 mins to go from Tuscaloosa, Alabama to Simpsonville, South Carolina.

The flight distance (direct flight from Tuscaloosa, AL to Simpsonville, SC) is 322.25 mi.

356 mi = 572.76 kms