There are
2,306 mi
from Tuscaloosa, AL to San Mateo, CA
That's the driving distance. It would take 1 day 16 hours to go from Tuscaloosa, Alabama to San Mateo, California.
The flight distance (direct flight from Tuscaloosa, AL to San Mateo, CA) is 1,969.44 mi.
2,306 mi = 3,710.74 kms