There are
372 mi
from Tuscaloosa, AL to Owensboro, KY
That's the driving distance. It would take 6 hours 58 mins to go from Tuscaloosa, Alabama to Owensboro, Kentucky.
The flight distance (direct flight from Tuscaloosa, AL to Owensboro, KY) is 316.26 mi.
372 mi = 598.35 kms