There are
352 mi
from Tuscaloosa, AL to Madisonville, KY
That's the driving distance. It would take 6 hours 25 mins to go from Tuscaloosa, Alabama to Madisonville, Kentucky.
The flight distance (direct flight from Tuscaloosa, AL to Madisonville, KY) is 284.57 mi.
352 mi = 565.70 kms