There are
613 mi
from Tuscaloosa, AL to Hannibal, MO
That's the driving distance. It would take 11 hours 38 mins to go from Tuscaloosa, Alabama to Hannibal, Missouri.
The flight distance (direct flight from Tuscaloosa, AL to Hannibal, MO) is 495.80 mi.
613 mi = 986.22 kms