There are
400 mi
from Tuscaloosa, AL to Cape Girardeau, MO
That's the driving distance. It would take 7 hours 34 mins to go from Tuscaloosa, Alabama to Cape Girardeau, Missouri.
The flight distance (direct flight from Tuscaloosa, AL to Cape Girardeau, MO) is 303.60 mi.
400 mi = 642.93 kms