There are
259 mi
from Topeka, KS to South Sioux City, NE
That's the driving distance. It would take 4 hours 58 mins to go from Topeka, Kansas to South Sioux City, Nebraska.
The flight distance (direct flight from Topeka, KS to South Sioux City, NE) is 238.64 mi.
259 mi = 417.58 kms