There are
622 mi
from Topeka, KS to Clarksdale, MS
That's the driving distance. It would take 11 hours 22 mins to go from Topeka, Kansas to Clarksdale, Mississippi.
The flight distance (direct flight from Topeka, KS to Clarksdale, MS) is 439.26 mi.
622 mi = 1,000.25 kms