There are
412 mi
from Topeka, KS to Cape Girardeau, MO
That's the driving distance. It would take 7 hours 45 mins to go from Topeka, Kansas to Cape Girardeau, Missouri.
The flight distance (direct flight from Topeka, KS to Cape Girardeau, MO) is 356.20 mi.
412 mi = 662.66 kms