There are
1,449 mi
from Tempe, AZ to St Charles, MO
That's the driving distance. It would take 1 day 1 hour to go from Tempe, Arizona to St Charles, Missouri.
The flight distance (direct flight from Tempe, AZ to St Charles, MO) is 1,248.82 mi.
1,449 mi = 1.61 kms