There are
1,842 mi
from Temecula, CA to Sikeston, MO
That's the driving distance. It would take 1 day 8 hours to go from Temecula, California to Sikeston, Missouri.
The flight distance (direct flight from Temecula, CA to Sikeston, MO) is 1,568.20 mi.
1,842 mi = 1.61 kms