There are
353 mi
from Temecula, CA to Mesquite, NV
That's the driving distance. It would take 6 hours 23 mins to go from Temecula, California to Mesquite, Nevada.
The flight distance (direct flight from Temecula, CA to Mesquite, NV) is 287.47 mi.
353 mi = 568.21 kms