Miles between Tallahassee, FL and Sikeston, MO

There are
645 mi
from Tallahassee, FL to Sikeston, MO

That's the driving distance. It would take 12 hours 41 mins to go from Tallahassee, Florida to Sikeston, Missouri.

The flight distance (direct flight from Tallahassee, FL to Sikeston, MO) is 539.26 mi.

645 mi = 1,037.46 kms