There are
622 mi
from Tallahassee, FL to Paducah, KY
That's the driving distance. It would take 11 hours 57 mins to go from Tallahassee, Florida to Paducah, Kentucky.
The flight distance (direct flight from Tallahassee, FL to Paducah, KY) is 521.72 mi.
622 mi = 1,001.36 kms