There are
798 mi
from Tallahassee, FL to Edwardsville, IL
That's the driving distance. It would take 15 hours 11 mins to go from Tallahassee, Florida to Edwardsville, Illinois.
The flight distance (direct flight from Tallahassee, FL to Edwardsville, IL) is 661.99 mi.
798 mi = 1,284.67 kms