There are
377 mi
from Tallahassee, FL to Cayce, SC
That's the driving distance. It would take 7 hours 57 mins to go from Tallahassee, Florida to Cayce, South Carolina.
The flight distance (direct flight from Tallahassee, FL to Cayce, SC) is 307.44 mi.
377 mi = 606.27 kms