There are
2,233 mi
from Summerville, SC to Mesquite, NV
That's the driving distance. It would take 1 day 16 hours to go from Summerville, South Carolina to Mesquite, Nevada.
The flight distance (direct flight from Summerville, SC to Mesquite, NV) is 1,927.83 mi.
2,233 mi = 3,593.69 kms