There are
743 mi
from Sugar Land, TX to Cape Girardeau, MO
That's the driving distance. It would take 13 hours 26 mins to go from Sugar Land, Texas to Cape Girardeau, Missouri.
The flight distance (direct flight from Sugar Land, TX to Cape Girardeau, MO) is 637.08 mi.
743 mi = 1,195.79 kms