There are
1,645 mi
from St Petersburg, FL to Sioux Falls, SD
That's the driving distance. It would take 1 day 6 hours to go from St Petersburg, Florida to Sioux Falls, South Dakota.
The flight distance (direct flight from St Petersburg, FL to Sioux Falls, SD) is 1,341.69 mi.
1,645 mi = 1.61 kms