There are
931 mi
from St Petersburg, FL to Cape Girardeau, MO
That's the driving distance. It would take 17 hours 29 mins to go from St Petersburg, Florida to Cape Girardeau, Missouri.
The flight distance (direct flight from St Petersburg, FL to Cape Girardeau, MO) is 770.36 mi.
931 mi = 1,498.54 kms