Miles between St Louis, MO and Lisle, IL

There are
280 mi
from St Louis, MO to Lisle, IL

That's the driving distance. It would take 5 hours 13 mins to go from St Louis, Missouri to Lisle, Illinois.

The flight distance (direct flight from St Louis, MO to Lisle, IL) is 246.28 mi.

280 mi = 450.15 kms