Miles between St Louis, MO and Desoto, TX

There are
645 mi
from St Louis, MO to Desoto, TX

That's the driving distance. It would take 12 hours 6 mins to go from St Louis, Missouri to Desoto, Texas.

The flight distance (direct flight from St Louis, MO to Desoto, TX) is 559.88 mi.

645 mi = 1,037.98 kms