There are
641 mi
from St Joseph, MO to Nicholasville, KY
That's the driving distance. It would take 12 hours 8 mins to go from St Joseph, Missouri to Nicholasville, Kentucky.
The flight distance (direct flight from St Joseph, MO to Nicholasville, KY) is 567.18 mi.
641 mi = 1,032.26 kms