There are
615 mi
from St Joseph, MO to Lawrenceburg, KY
That's the driving distance. It would take 11 hours 35 mins to go from St Joseph, Missouri to Lawrenceburg, Kentucky.
The flight distance (direct flight from St Joseph, MO to Lawrenceburg, KY) is 547.25 mi.
615 mi = 989.20 kms