There are
1,609 mi
from St George, UT to Sikeston, MO
That's the driving distance. It would take 1 day 4 hours to go from St George, Utah to Sikeston, Missouri.
The flight distance (direct flight from St George, UT to Sikeston, MO) is 1,320.57 mi.
1,609 mi = 1.61 kms