There are
280 mi
from St Clair Shores, MI to Dyer, IN
That's the driving distance. It would take 5 hours 15 mins to go from St Clair Shores, Michigan to Dyer, Indiana.
The flight distance (direct flight from St Clair Shores, MI to Dyer, IN) is 247.56 mi.
280 mi = 450.81 kms