There are
350 mi
from St Clair Shores, MI to Antioch, IL
That's the driving distance. It would take 6 hours 43 mins to go from St Clair Shores, Michigan to Antioch, Illinois.
The flight distance (direct flight from St Clair Shores, MI to Antioch, IL) is 265.15 mi.
350 mi = 562.74 kms