There are
387 mi
from St Charles, MO to Waunakee, WI
That's the driving distance. It would take 7 hours 12 mins to go from St Charles, Missouri to Waunakee, Wisconsin.
The flight distance (direct flight from St Charles, MO to Waunakee, WI) is 309.17 mi.
387 mi = 623.10 kms