There are
1,794 mi
from St Charles, MO to Upland, CA
That's the driving distance. It would take 1 day 7 hours to go from St Charles, Missouri to Upland, California.
The flight distance (direct flight from St Charles, MO to Upland, CA) is 1,536.70 mi.
1,794 mi = 2,886.38 kms