There are
1,245 mi
from St Charles, MO to Sweetwater, FL
That's the driving distance. It would take 22 hours 47 mins to go from St Charles, Missouri to Sweetwater, Florida.
The flight distance (direct flight from St Charles, MO to Sweetwater, FL) is 1,075.70 mi.
1,245 mi = 2,003.39 kms