There are
2,016 mi
from St Charles, MO to Sonoma, CA
That's the driving distance. It would take 1 day 10 hours to go from St Charles, Missouri to Sonoma, California.
The flight distance (direct flight from St Charles, MO to Sonoma, CA) is 1,717.95 mi.
2,016 mi = 3,244.45 kms