There are
1,814 mi
from St Charles, MO to Sierra Madre, CA
That's the driving distance. It would take 1 day 7 hours to go from St Charles, Missouri to Sierra Madre, California.
The flight distance (direct flight from St Charles, MO to Sierra Madre, CA) is 1,556.95 mi.
1,814 mi = 2,919.70 kms