There are
442 mi
from St Charles, MO to Sheboygan, WI
That's the driving distance. It would take 8 hours 26 mins to go from St Charles, Missouri to Sheboygan, Wisconsin.
The flight distance (direct flight from St Charles, MO to Sheboygan, WI) is 372.29 mi.
442 mi = 711.75 kms