There are
2,052 mi
from St Charles, MO to San Mateo, CA
That's the driving distance. It would take 1 day 11 hours to go from St Charles, Missouri to San Mateo, California.
The flight distance (direct flight from St Charles, MO to San Mateo, CA) is 1,721.36 mi.
2,052 mi = 3,302.75 kms