There are
1,818 mi
from St Charles, MO to Reno, NV
That's the driving distance. It would take 1 day 7 hours to go from St Charles, Missouri to Reno, Nevada.
The flight distance (direct flight from St Charles, MO to Reno, NV) is 1,563.74 mi.
1,818 mi = 2,925.68 kms