There are
1,016 mi
from St Charles, MO to Poughkeepsie, NY
That's the driving distance. It would take 19 hours 8 mins to go from St Charles, Missouri to Poughkeepsie, New York.
The flight distance (direct flight from St Charles, MO to Poughkeepsie, NY) is 896.27 mi.
1,016 mi = 1,634.62 kms